2 edition of microiontophoretic study of opiates and opioid peptides in the rat brain stem. found in the catalog.
microiontophoretic study of opiates and opioid peptides in the rat brain stem.
Lynn Alison Lambert
Thesis (Ph.D.) - University of Birmingham, Dept of Pharmacology.
In the present study, we compared the autoradiographic distribution of I[Tyr14]OFQ and I[Tyr10]OFQ(1–11) in coronal rat brain sections. Nonspecific binding was . Such peptides may be produced by the body itself, for example endorphins. The effects of these peptides vary, but they all resemble those of opiates. Brain opioid peptide systems are known to play an important role in motivation, emotion, attachment behaviour, the response to stress and pain, and the control of food intake.
of opiate alkaloids or opioid peptides in most brain regions is de pression of spontaneous, synaptically or chemically-evoked neuronal single-unit discharge activity. The depressions are generally blocked by naloxone, suggesting involvement of the empirically defined opiate receptors. The depressions are qualitatively similar throughout the. brain stem, where GABA acts to inhibit a pain-inhibitory neuron). This disinhibitory action of the opioid has the net effect of exciting a descending inhibitory circuit. The opioid receptors are part of an endogenous opioid system that includes a large number of endogenous opi-oid peptide ligands. Based on cloning, three distinct.
When opioid drugs infiltrate a part of the brain stem called the locus ceruleus, their receptors slow respiration, cause constipation, lower blood pressure and decrease alertness. ABSTRACT The brain peptides a- and 3-endorphin, leucine- and methionine-enkephalin, as well as the opiate normorphine, have been evaluated by microiontophoresis for their effects on neuronal activity in several regions of the rat brain.
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The effects of microiontophoretically applied morphine and its interactions with the effects of microiontophoretic applications of either acetylcholine, (–)‐noradrenaline or 5‐hydroxytryptamine have been studied on single neurones in the brain stem of rats anaesthetized with by: The actions of mu- delta- and kappa-opiate receptor agonists have been compared on the activity of single neurones in the brain stem, caudate nucleus and hippocampus of the rat, using the technique of by: Terenius L.
Opioid peptides and opiates differ in receptor selectivity. Psychoneuroendocrinology. ; 2 (1)– Satoh M, Zieglgänsberger W, Fries W, Herz A.
Opiate agonist-antagonist interaction at cortical neurones of naive and tolerant/dependent rats. Brain Res. Dec 27; Cited by: Most opiate studies to date have concentrated on the neostriatum (caudate nucleus and putamen) and have, in general, ignored the paleostriatum or globus pallidus.
The globus pallidus has a moderate but diffuse distribution of opiate receptors comparable to that of the gray matter of the brain stem Cited by: A microiontophoretic study of the actions of μ‐, δ‐ and κ‐opiate receptor agonists in the rat brain P.B.
Bradley Department of Pharmacology, University of Birmingham, The Cited by: Studies using diverse techniques have demonstrated that some CNS structures have been the loci of the effect of the opiate, particularly those lining the ventricular system in the lower brain stem and di- encephalon (Herz et al., ; Schubert et al., ).
Mehnaz Ferdousi, David P. Finn, in Progress in Brain Research, Genetic studies. Knockout mice with deletions of specific genes encoding opioid receptors and peptides have extended the findings from pharmacological studies and facilitated our understanding of how the opioid.
(+)-Naloxone was tested, using the technique of microiontophoresis, for its ability to antagonise the depressant effects of opioid peptides on rat med. Opiate and opioid peptide effects on brain stem neurons: Relevance to nociception and antinociceptive mechanisms Author links open overlay panel G.F.
Gebhart Show more. Atweh SF, Kuhar MJ. Autoradiographic localization of opiate receptors in rat brain. The brain stem. Brain Res.
Jun 24; (1):1– [Google Scholar] Simantov R, Snyder SH. Opiate receptor binding in the pituitary gland. Brain Res. Gebhart G () Opiate and Opioid Peptide Effects on Brain Stem Neurons: Relevance to Nociception and Antinociceptive Mechanisms. Pain – Google Scholar 9. and brain stem. Most enkephalin-containing neurons have short axons, indicating that enkephalins act close to their points of synthesis.
The distribution of neurons containing the other two types of opioid peptides— beta-endorphin and the dynor-phins— is not as. Bradley PB, Dray A. Morphine and neurotransmitter substances: Microiontophoretic study in the rat brain stem.
Br J Pharmacol. Jan; 50 (1)– [Europe PMC free article] [Google Scholar] Bramwell GJ, Bradley PB. Actions and interactions of narcotic agonists and antagonists on brain stem neurones.
Brain Res. Jun 14; 73 (1)– Abstract. It has now been nearly 10 years since the isolation and identification of the first opioid peptides, Met- and Leu-enkephalin (Hughes, ; Hughes et al., ), and somewhat longer since the demonstration of specific opiate-binding sites in brain tissue (Pert & Snyder, ; Simon et al., ; Terenius, ), and the observation that electrical stimulation of particular brain loci.
Distribution of the potent opioid peptide dynorphin has been determined in pituitary gland (pig, beef, rat), in the various regions of rat brain, and in rat spinal cord, by using a highly specific. Lindberg, I. and Yang, H.-Y. () Distribition of mets-enkephalin-are-gly -leu8-immunoreactive peptides in rat brain: Presence of multiple molecular forms.
Brain. PHARMACOLOGICAL AND ELECTROPHYSIOLOGICAL STUDIES OF MORPHINE AND ENKEPHALIN ON RAT SUPRASPINAL NEURONES AND CAT SPINAL NEURONES.
a microiontophoretic study, Brain Research, /(90)H, (), ( Opiate and opioid peptide effects on brain stem neurons: Relevance to nociception and antinociceptive. Measurement of pain; Prototype for the quantitative study of subjective sensations.
Opiate and opioid peptide effects on brain stem neurons: Relevance to nociception and antinociceptive mechanisms. Differential effects of morphine and opioid analgesics on A and C fibre-evoked activity in ascending axons of the rat spinal cord.
Brain. Bradley PB, Dray A. Morphine and neurotransmitter substances: Microiontophoretic study in the rat brain stem. Br J Pharmacol. Jan; 50 (1)– [PMC free article] Bramwell GJ, Bradley PB. Actions and interactions of narcotic agonists and antagonists on brain stem neurones.
Brain Res. Jun 14; 73 (1)– Considering first the brain stem, opiate agonists a Evoked Activity in Ascending Axons of the Rat Spinal Cord. Brain Res – The in vivo study of opiates and opioid peptides is.
This system can be activated by opiate administration or by electrical stimulation of discrete brain-stem sites. Evidence is presented that its pain-suppressing action is mediated, at least in part, by endogenous opiate-like compounds (endorphins).
R.A. Opiates, opioid peptides and single neurons. Life Sci. – PubMed.Other articles where Opioid peptide is discussed: hypothalamus: Hypothalamic regulation of hormone secretion: Well-known examples are the opioids (e.g., enkephalins), so named because they are endogenous (produced in the human body) peptides (short chains of amino acids) with a strong affinity for the receptors that bind opiate drugs, such as morphine and heroin.Belcher G, Ryall RW.
Differential excitatory and inhibitory effects of opiates on non-nociceptive and nociceptive neurones in the spinal cord of the cat. Brain Res. Apr 28; (2)– Bradley PB, Dray A.
Morphine and neurotransmitter substances: Microiontophoretic study in the rat brain stem. Br J Pharmacol. Jan; 50 (1)–